South Meseta is lower than the North Meseta. Also is drier and warmer, winter could be cold specially at nights. For me the most interesting natural thing is a big aquifer that we call the 23. Is very big but with too much use, lot of years with problems like subterranean fire for a natural process.
Another important thing of the region are big number of castles and the windmills. Don Quijote the most important Spanish novel is in this area, he fight against the wind mills.
There are lot of places to visit following the famous novel, based in Argamasilla de Alba. There are a cave to visit and lot of windmills is a cultural visit to understand this landscape.
Madrid and Toledo are the main cities to visit in this region if you like the history and need to see urban architecture.
The Meseta is flat with some hills but you only see mountains when you arrive to the end or you go down into a river that can form a Canyon like the Jucar River.
The wines are also important is this region where isn’t easy to find a shadow in the warm summer. Trees aren’t in this area, only in the mountains and areas near the rivers.
My favorite place in the region is following the Guadiana river, even now isn’t totally clear where is born. Lagunas de Ruidera are the place that appears in most of the books. Sometimes is a subterranean river in the famous 23 aquifer. There the eyes of Guadiana where originally appears the Guadiana again. The irregular rain, and specially the massive use of water for the agriculture is a danger for this amazing natural water aquifer.
Enjoy this region with good roads in a flat area where the trips are easy.